What with every other roleplaying book being either a coffee table book or half eye candy, I'm rather pleased to find Microscope's PDF in black and white. I had no problems reading it on an iPad or on Acrobat on a PC. Given the rule's lack of charts and stat blocks, I'm not sure how much I really need to print.
Microscope is an 81-page black and white PDF with no art and single-column layout. The PDF comes with a one-page reference sheet. The single-column layout uses an eye-friendly sized font, with new subjects starting on their own page titled in large bold letters. This makes it easy to look up a rule or other piece of information.
As other reviews have suggested, the rules are conceptually different from conventional "skill roll" roleplaying games. The game has no charts or stat blocks, so you won't be looking up this sort of information in the game. You may need to look up a specific rule. So, for those who do wish to print out the rulebook, you may wish to print it out into two sections, about 50 pages of rules, and maybe 12 pages of play advice. The remaining pages are game designer notes. Personally, I'd make a few tweaks to the PDF for better printing, such as no title pages predominantly in black.
Overall: 4.5 / 5.0. Good job.
[5 of 5 Stars!]